Testing for phospholipid antibodies is indicated in the following clinical situations:
-Unexplained arterial or venous thrombosis
-A history of pregnancy morbidity defined as 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation, 1 or more premature births before 34 weeks of gestation caused by severe preeclampsia or placental insufficiency, or 3 or more unexplained, consecutive spontaneous abortions before the 10th week of gestation with no identifiable maternal hormonal or anatomic, or maternal or paternal chromosomal causes
-Presence of an unexplained cutaneous circulatory disturbance, eg, livido reticularis or pyoderma gangrenosum
-Presence of a systemic rheumatic disease especially lupus erythematosus
-Unexplained thrombocytopenia or hemolytic anemia
-Possible nonbacterial, thrombotic endocarditis