Herpes Simplex Virus (HSV) 1 & 2, IgG, Serum
Alias:
HSVAGM, HSV Glycoprotein 1 and 2, HSV IgM, Herpes IgM
Methodology:
Performed:
Analytical Time:
Testing Laboratory:
Laboratory Section:
Interpretive Data:
Note that HSV IgM testing was discontinued by Mayo Medical Laboratories effective 12/03/2019;
Explanation: HSV IgM testing has several limitations, including 1) the inability to accurately differentiate between HSV-1 and
HSV-2, 2) prolonged time (10-21 days) between infection and seroconversion, and 3) prolonged positivity (3-6
months or longer) of anti-HSV IgM antibodies following infection. Collectively, these characteristics significantly
limit the use of anti-HSV IgM as a marker of acute or recent HSV infection.
Furthermore, the Centers for Disease Control and Prevention (CDC), the Infectious Diseases Society of
America (IDSA) and the American Academy of Pediatrics (AAP) do not recommend anti-HSV IgM testing.
Therefore, to align with the guidance from the CDC and IDSA, MCL will discontinue offering HSV IgM testing.
As alternatives to HSV IgM testing, for diagnosis of acute HSV infection UPHDM recommends molecular testing
for clinically-affected areas (e.g., genital or dermal lesions, blood, CSF). For determination of patient exposure
history to HSV, UPHDM recommends type-specific HSV IgG testing (Epic LAB4039/Sunquest HSVGM)
Herpes Simplex Virus (HSV) 1 & 2, IgG, Serum
Preferred Collection Container:
Also Acceptable Collection Container:
Collection Information:
Collect blood in a serum separator tube or red serum tube.
Transport Information:
Spin down and send 0.6 mL of serum refrigerated.
Minimum Sample Volume: 
0.4 mL of serum (approximately 0.8 mL of whole blood based upon normal patient hematocrit)
Stability
Refrigerated Stability:
Frozen Stability:
Ambient Stability:
Herpes Simplex Virus (HSV) 1 & 2, IgG, Serum
Sunquest Order Code:
Epic Number: CPT Code:
86695-Herpes simplex, type 1; 86696-Herpes simplex, type 2
Herpes Simplex Virus (HSV) 1 & 2, IgG, Serum
Modified: