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Epstein-Barr Virus (EBV) Antibody Profile

Alias:

Anti EBV Serology, E. B. (Epstein-Barr) Virus, EBNA (Epstein-Barr Nuclear Antigen), EBV (Epstein-Barr Virus) Battery, EBV (Epstein-Barr Virus) Panel, EBV (Epstein-Barr Virus), EBV Panel, Serum, Epstein Barr Virus, Epstein-Barr Virus AB, Epstein-Barr Virus Battery, Epstein-Barr Virus Panel, VCA (Viral Capsid Antigen) IgG and IgM, Viral Capsid Antigen (VCA) Titer, Infectious Mononucleosis, EBV Ab, Serum

Methodology:

Multiplex Flow Immunoassay (MFI)

Analytical Time:

1 day

Testing Laboratory:

Pathology Laboratory

Laboratory Section:

Core Laboratory

Interpretive Data:

Antibody	Timing of when the antibody is typically detected in the blood
Viral Capsid Antigen (VCA)-IgM antibody	Appears first after exposure to the virus and then tends to disappear after about 4 to 6 weeks
VCA-IgG antibody	Emerges during acute infection with the highest level at 2 to 4 weeks, then drops slightly, stabilizes, and is present for life
Early Antigen (EA-D) antibody	Appears during the acute infection phase and then tends to disappear; about 20% of those infected will continue to have detectable quantities for several years after the EBV infection has resolved.
Epstein-Barr Nuclear Antigen (EBNA) antibody	Does not usually appear until the acute infection has resolved; it develops about 2 to 4 months after the initial infection and is then is present for life.

Epstein-Barr Virus (EBV) Antibody Profile

Preferred Collection Container:

SST (Serum Separator)
Light Green (Lithium Heparin Plasma Separator Tube)

Also Acceptable Collection Container:

Red (No Additive)
Green No Gel (Lithium Heparin)

Collection Information:

Collect blood in a serum separator tube or Light Green (Lithium Heparin Plasma Separator Tube).

Transport Information:

Centrifuge and aliquot 1.0 mL of serum into a plastic transport vial. Send refrigerated.

Minimum Sample Volume: Minimum amount of analytical sample (serum, plasma, urine, CSF, etc.) required to perform an assay once. Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory or reflex testing. In some situations, a minimum specimen volume may result in a QNS (Quantity Not Sufficient) result, requiring a second specimen to be collected.

Minimum amount of analytical sample (serum, plasma, urine, CSF, etc.) required to perform an assay once. Submitting the minimum volume makes it impossible to repeat the test or perform confirmatory or reflex testing. In some situations, a minimum specimen volume may result in a QNS (Quantity Not Sufficient) result, requiring a second specimen to be collected.

0.25 mL of serum (approximately 0.5 mL of whole blood based upon a normal patient hematocrit)

Unacceptable Conditions:

Gross hemolysis

Stability

Refrigerated Stability:

7 days - Preferred

Frozen Stability:

Indefinitely

Epstein-Barr Virus (EBV) Antibody Profile

Sunquest Order Code:

EBVBAT

Epic Number: The test code used to identify this assay in Epic

LAB5480

CPT Code:

86664/EBNA; 86665/x2 VCA, IgG & IgM

Epstein-Barr Virus (EBV) Antibody Profile

Modified:

1/19/2012 6:46:40 AM